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As observed previously (4), the parent peptide GLP-1 also retained its ability to protect the heart from IRI in the absence of a functional GLP-1R (Figure 1F, white bars)

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Michaeli S, Oz G, Sorce DJ, Garwood M, Ugurbil K, Majestic S, et al

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The UPS mediates the selective degradation of proteins that participate in diverse cellular processes, thereby maintaining a fine balance of cellular activities

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Since GLP-1 and PYY are co-secreted from L-cells 24 , the failure of cinnamaldehyde and methyl syringate to raise circulating levels of GLP-1 seems paradoxical

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